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Overall, these studies highlight the role of adipocyte lipolysis in inter-organ crosstalk through the release of lipid signals and EVs to regulate whole body tissue homeostasis (Figure 4)

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For CIDP, evidence is also emerging that patients previously maintained on IVIg treatment may undergo disease worsening upon switching to FcRn antagonists, underlining the fact that other disease drivers than solely auto-Abs are also vital aspects of pathophysiology in at least certain patients with CIDP [265, 401, 402]

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