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The suggestion that carnitine deficiency may lead to frailty through mitochondrial dysfunction (117) has been examined in one trial

One major limitation of this study beyond its retrospective design is that patients who received L-carnitine had a significantly different clinical presentation

(More information) Other Articles Introduction L-Carnitine (-hydroxy--N-trimethylaminobutyric acid) is a derivative of the amino acid, lysine ( Figure 1 )
Finally, a number of inherited mutations in genes involved in carnitine shuttling and fatty acid oxidation pathways do not systematically result in carnitine depletion (such that carnitine supplementation may not help mitigate the symptoms) but lead to abnormal profiles of acylcarnitine esters in blood (35, 40)
