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A skin biopsy, measurement of metabolites (such as serum methyl malonic acid and homocysteine), and a Schilling test would have thrown more light on the diagnosis
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Electrophysiological recordings further supported this, revealing that Dihexa caused a 1.6-fold increase and Nle-AngIV caused a 1.7-fold increase in the frequency of AMPA-mediated mEPSCs compared to vehicle-treated neurons, indicating an expansion of functional synapses without altering individual synapse properties such as amplitude, rise, or decay times
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JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
