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This is because it is a sensitive molecule that is not located in a controlled environment within the cell, as is the case with most enzymes, but functions outside the cell and is thus exposed to various disruptive influences

This preservative helps prevent bacterial growth in multi-dose vials, making it preferred for reconstituted peptides that will be stored for multiple uses

[DOI] [PMC free article] [PubMed] [Google Scholar] 51.James L.P., Simpson P.M., Farrar H.C

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The result is twofold: Lower NAD+: The cell has less fuel for metabolism