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A liposome is a tiny bubble made of the same material as your cell membranes (phospholipids)

NCOA4 can mediate ferritinophagy, while it is degraded via HERC2 ubiquitination-mediated induction of the proteasomal degradation machinery in the presence of iron (21)

This genomic flexibility, coupled with specific mutations in drug targets, overexpression of efflux transporters, and alterations in sterol biosynthesis pathways, enables Leishmania to withstand various therapeutic interventions and develop resistance to multiple drugs

313,314 In one study, OA was induced in rats by injecting MIA into the knee joint, mimicking the pathological changes of human OA