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The BBB, similar to the peripheral vasculature, is susceptible to degradation and dysfunction of endothelial cells through oxidative stress, inflammation, and mechanical hemodynamic stress (i.e., high systolic pressures and pulsatility) (Moyaert et al., 2023

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A native gene would enable knockout models, expression mapping and antibody validation

Ideally, look for a comprehensive calcium supplement combining calcium, magnesium, and vitamin D3, as all these nutrients are essential for optimal bone health

doi: 10.1002/jps.10578