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The detection approach used in this study was based on the fluorescence resonance energy transfer (FRET) method using silver ions (Ag + ) and yellow color light-emitting 2,3-diaminophenazine (OxOPD) as the redox components

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Unlike native IGF-1, which requires frequent administration due to its short half-life and extensive IGFBP binding, IGF-1 LR3's enhanced stability and bioavailability make it a more practical candidate for investigating growth factor-mediated tissue regeneration and metabolic regulation

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Briefly, mRNA libraries were produced using the Illumina NovaSeq platform where single-end reads were sequenced to a depth of approximately 2025 10 6 reads per sample

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