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[3] This fragment was further observed to lack the mitogenic, proliferative, and insulinotropic activity associated with the N-terminal and central domains of hGH, which include residues responsible for binding to the hGH receptor and stimulating IGF-1 production

The extra boost from the B12 is great

PLoS ONE 5 , e8547 (2010)

Meaning less cellular energy production and impaired mitochondrial function

They suggest that taking 2mg or less per day is unlikely to cause any negative effects

Patterns of Failure for Recurrent Head and Neck Squamous Cell Carcinoma Treated With Salvage Surgery and Reirradiation using IMRT