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Metabolic signaling operates bidirectionally, in that cellular signaling can reprogram metabolism, while metabolites play critical roles in multiple signaling pathways

It is well documented that patients suffering from SOD1-associated fALS have variable survival times, dependent upon the particular amino acid mutation 18

The figure shows that the histograms of body height and body mass distribution of in children with ESLD differ significantly from the normal distribution curves and are shifted to lower values

Blood (2018) 131(23):258193