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In vitro pull-down and mass analyses revealed a series of enzymes (carbonyl reductase, glutathione-S-transferase, glyoxalase, etc.) that function in a reactive oxygen species (ROS) metabolic pathway as curcumin-binding targets, the expression of which was up-regulated in human leukemia
ALA pretreatment of breast cancer cell lines increases cell sensitivity to ionizing radiation and blocks transforming growth factor beta signaling inhibiting the migration and invasion of metastatic breast cancer cells [91]
