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Likewise, berberine, isolated from Coptis chinensis and Hydrastis canadensis , exhibits notable biofilm-inhibitory effects, especially in combination with miconazole (Wei et al., 2011)

Endocrine disorders: Hyperprolactinemia General disorders and administration site conditions: Edema peripheral Hepatobiliary disorders: Hepatitis, hepatic failure Investigations: Liver enzyme elevations Psychiatric disorders: Hypomania, mania Reproductive system and breast disorders: Gynecomastia, galactorrhea Skin and subcutaneous tissue disorders: Photosensitivity reaction, angioedema, Stevens-Johnson syndrome Table 4 includes clinically significant drug interactions with alprazolam tablets [see Clinical Pharmacology (12.3)]

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Once the gut barrier is damaged, so too is the gut-brain barrier