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Up to 29% of cases recur within five years after primary surgery, and only one third of CRC diagnoses are localized at the time of detection ( The persistently low survival rates and high recurrence of CRC can be attributed to cancers ability to develop resistance against existing therapies ( 2 Mechanisms of chemotherapy resistance in CRC 2.1 Resistance due to modulation of cell death pathways 2.1.1 Evasion of apoptosis Apoptosis is a natural process of programmed cell death, allowing for the regulation of homeostasis through the maintenance of normal cells and embryonic development ( p53 is a crucial tumor suppressor that responds to a variety of stress signals, including DNA damage and oncogene activation

When multiple papers from a single study had been published, we used the latest publication and supplemented it with data from the earlier publication(s)

Nrf2 mediates the induction of ferritin H in response to xenobiotics and cancer chemopreventive dithiolethiones

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Manufacturing under recognized quality standards such as ISO 22716 provides reassurance that the production environment follows structured procedures for quality control, hygiene, and documentation