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Constipation is common because slower transit means more water absorption from the stool

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This drives severe oxidative stress in neural and hepatic tissue, aggressively countering the intended neuroprotective goals of a longevity protocol

While ligand targeting of Alzheimer's pathology (e.g., hyperphosphorylated tau and A plaques) is further incorporated as the ultimate objective, enabling specific delivery with triggered release of therapeutic agents at the pathological site (Pawar et al., 2025

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Intracranial (superior sagittal sinus) hypertension, portal and caval hypertension, aortal hypotension, progressing venous and arterial thrombosis peripherally and centrally, and ECG disturbances [14,15,16,20,22,23,24,25] were commonly counteracted