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& Cao, M

The chief site of systemic toxicity is the heart while liver is susceptible because, unlike other organs it is capable of clearing nontransferrin-bound iron [199]

A great deal of GH biology is thought to depend on the pattern of exposure, not just the total amount: pulsatile GH and continuous GH can produce different downstream gene-expression and metabolic effects in target tissues, which is one reason natural secretion is so tightly pulsatile in the first place

With an additional change of the CGFS signature to CSYC, reduction of roGFP2 increased only slightly (approximately to 1.8% of class I HsGRX2), but HED activity was increased more efficiently (approximately to 2.5% of class I HsGRX2) 14
