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PDE-4 inhibitors act as anti-inflammatory agents that can increase cyclic AMP in inflammatory cells and inhibit the breakdown of intracellular cyclic nucleotides

Circulation 100 : 11611168 Chambers JC, McGregor A, Jean-Marie J, Obeid OA and Kooner JS (1999) Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia

Jha N, Kumar MJ, Boonplueang R, Andersen JK

Numerous factors, including host genetics, nutrition, health state, aging, and the use of antibiotics, affect the gut microbiota composition, which has high inter-individual variability

strain LMB-5 [22], Microbacterium sp

Clinical tip: Epithalon is always a standalone protocol