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J Pathol J Pathol Soc Gt Br Irel

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doi: 10.1016/j.jfma.2017.09.006

although neurotoxicity was more prominent for linear GBCAs, both linear and macrocyclic GBCAs triggered neuronal cell death, through activation of apoptosis [34]

These cells decide if scars form or if tissue heals perfectly

Aside from such examples of myelin/OLG relevant genes identified through GWAS, transcriptomic analyses reveal gene expression changes in additional myelin-related genes in a broad range of neurodegenerative diseases, including AD [3], PSP [3], MSA [82], and frontotemporal lobar degeneration (FTLD) [39], further supporting the idea of myelination changes as a common pathway across these diseases