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10.1124/jpet.122.001194 19 HayA.DziewulskaK.GamboniF.NerguizianD.DzieciatkowskaM.ZimringJ

Daratumumab triggers CD38 + multiple myeloma cells [via antibody-dependent cellular cytotoxicity (ADCC), complement dependent cytotoxicity (CDC), and tumor-associated macrophages (TAMs)] in sensitive and drug-resistant patients, regulates the enzyme activity of CD38, reduces the level of adenosine and reduces adenosine-induced immunosuppression

The -globin and -globin proteins were also observed in hippocampal and cortical astrocytes and in most oligodendrocytes in the mouse brain (151), although these findings in mouse brains were not replicated in a separate study (153)