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We further used this larger population to assess whether specific factors, such as age, gender, disease duration and severity, or medication use might interact with the changes observed with NAC

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Genetic factors such as p53 and nuclear factor erythroid 2-related factor 2 (Nrf2) also affect susceptibility by regulating the expression of solute carrier family 7 member 11 (SLC7A11) or influencing antioxidant defenses [92]

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