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In this process, more free radicals are often created, causing oxidative damage, which has been implicated as the cause of many diseases, such as cardiovascular diseases, neurodegenerative diseases, arthritis, diabetes, obesity, osteoporosis, metabolic syndrome, cancer, strokes, atherosclerosis, chronic inflammation and also has an impact on the aging process of the body [6,14,17,23,24,26,28,29]

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Taken together, further work will be needed to determine the exact mechanisms of metformin against APAP hepatotoxicity

Antioxidants such as vitamins C and E given during pregnancy have not demonstrated any significant positive effects [12,13]

The GSH content was assayed enzymatically using high performance chromatography (HPLC)