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In chronic kidney disease (CKD), MGO plays a role in the progressive decline of kidney function through various mechanisms, including inflammation and fibrosis [270,271,272]

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Insulin resistance in the GPx1 overexpressing mice altered glucose metabolism and caused a type 2 diabetes phenotype, owing, in part, to a decrease in cellular - hydrogen peroxide that normally oxidatively inactivates protein phosphatases [100, 101]

The generated Mn 2+ displayed Fenton-like activity for enhanced CDT

Exercise-Induced Oxidative Stress Intense or prolonged exercise generates substantial oxidative stress through increased oxygen consumption and metabolic rate, increased mitochondrial electron leakage producing reactive oxygen species, recruitment of inflammatory immune cells to exercising muscles, and mechanical stress on tissues producing oxidative damage

10.1016/j.chemosphere.2011.04.022 Chemosphere 57 LoyallL.UchidaK.BraunS.FuruyaM.FrohnmeyerH