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Patients were randomly assigned to either the high-dose methotrexate arm or the control arm.[4] In the POG-9404 study, patients were also randomly assigned to receive doxorubicin with or without dexrazoxane to determine the efficacy of dexrazoxane in preventing late cardiac mortality.[7][Level of evidence B1] There was no difference in EFS between patients with T-ALL who were treated with dexrazoxane and patients who were not treated with dexrazoxane (cumulative doxorubicin dose, 360 mg/m2).[7] The frequency of grade 3 and grade 4 toxicities that occurred during therapy was similar between the randomized groups, and there was no difference in cumulative incidence of second malignant neoplasms

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Hand CE, Taylor NJ & Honek JF (2005) Ab initio studies of the properties of intracellular thiols ergothioneine and ovothiol

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Food ingredients influencing folate stability Some food ingredients and natural compounds may influence the stability of folates

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The mitochondrial transporter family (SLC25): physiological and pathological implications

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The formation of gamma-glutamylcysteine is the rate-limiting reaction in GSH synthesis and is feedback inhibited by GSH itself, a mechanism responsible for the regulation of cellular GSH concentration

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Research has shown that the antitumor activity of curcumin is linked to epigenetic mechanisms (also summarized in Table 1)

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