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Fe 3+ subsequently binds to transferrin (TF) or lactoferrin (LF) to form a TFFe 3+ complex, which is then recognized and internalized by transferrin receptor 1 (TFR1) on the cell surface ( 3+ is reduced to Fe 2+ via six-transmembrane epithelial antigen of prostate 3 (STEAP3) and transported into the cytosol by divalent metal transporter 1 (DMT1) and ZRT/IRT-like proteins 8 and 14 (ZIP8/14) ( 2+ is sequestered in ferritin in an inactive form, while a small fraction forms the labile iron pool (LIP)

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