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Cole, PharmD, BCPS Last Reviewed: August 2015 Hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, more commonly known as statins, are recommended as first-line agents in the reduction of low-density lipoprotein cholesterol (LDL-C).(1) Although cholesterol is imperative for normal cellular function, excess LCL-C leads to atherogenesis