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Notably, when Melanotan II-treated mice were compared to vehicle-treated pair-fed mice that lost equivalent body weight through caloric restriction, the Melanotan II group showed greater reductions in subcutaneous adipose tissue, suggesting effects beyond simple appetite suppression

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Information sources and search The literature was explored using the MEDLINE (via PubMed) and Web of Science databases, including all articles published from the inception up February 2020

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