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These data support a model where AMPARs and NMDARs are positioned to maximize functional efficiencywith AMPARs located for optimal activation by glutamate and NMDARs located close to the scaffolding nexus to maximize their role in the induction of plasticity

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At day 3 of adulthood worms were picked, washed with PBS and stained with 5 M of dihydroethdium (DHE, Invitrogen) in PBS for 45 min at 20 C with agitation

[DOI] [PMC free article] [PubMed] [Google Scholar] 25.Lenda DM, Boegehold MA

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26 The results from OpRegens phase 1/2a trial demonstrate a numerical improvement of an average of 6 letters in change in BCVA as well as a 2-point average increase in National Eye Institute Visual Function Questionnaire 25 quality of life scores for all cohorts of patients, with effects observed through 24 months following a single administration