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Patients are frequently identified with PD only in the presence of tremor and other symptoms, by which time 6080% of the substantia nigra (SN) dopamine neurons have been lost, which occurs 5 to 15 years after the start of neuronal degeneration (Sulzer et al., 2018) (see Figure 1)

While it is somehow explainable, because different models were used in the studies

Pro-angiogenic effects via VEGFR2-Akt-eNOS
