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There is no evidence that doses above 500mcg produce proportionally better results, and clinical trials using 1mg daily did not dramatically outperform lower doses

The arguments are its particular combination, such as antidepressant effect (Porsolts test, open field) [65] and region-specific influences on brain serotonin synthesis in rats given a particular increase in the substantia nigra [67] vs

Biomedicine & Pharmacotherapy, 175 , Article 116709

Cortical cell degeneration due to stress resulting from changes in hormonal balance may cause atrophy of the adrenal cortex, which was also reported in 1959 (McCarthy et al

Wirthensohn M, Wehrli S, Ljungblad UW, et al

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