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However, the limited human clinical trial data means that the long-term safety profile in humans is not fully characterized

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meanwhile, tepotinib inhibits c-Met signaling in both HGF-dependent and independent ways [156]

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[15] Serious but infrequent events-such as angioedema, bronchospasm, hypotension, or urticaria-reflect IgE-mediated hypersensitivity and may require desensitization or substitution with hydroxocobalamin
