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A deficiency can lead to a type of anemia called megaloblastic anemia, causing fatigue and weakness

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The associations were strongest for liver, lung, pancreatic cancers, and myeloid malignancies

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Oscillations of this core loop are followed by secondary, co-existing feedback loops involving REV-ERB , ROR , DBP , EFBP4 , TEF , HLF, and others 18,19,20