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53 Although some pharmacological therapies assist in the control of obesity, the majority of commonly used drugs are associated with adverse health effects 51 that include cardiovascular complications, possibly due to the formation of thrombi, insomnia, constipation, dry mouth, dizziness, dysgeusia, headache, fatigue, gastrointestinal symptoms, among others

Indeed, despite attempts to generate a egtA gliK mutant on multiple occasions, using a variety of strategies, no successful egtA gliK mutant was generated (unpublished observations), which indicates that the simultaneous absence of EgtA and GliK is not possible in A

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Nevertheless, low consumption of nuts (a key MedDiet component) and high consumption of sweets and commercially made pastries (typically consumed in low amounts as part of the MedDiet) was reported