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- Indirect inactivation of tyrosinase via antioxidant effect which leads to quenching of free radicals and peroxides

Overall, although limited, the evidence suggests a benefit of methyl-B12 for children with ASD

Abbreviations AMPK AMP-activated protein kinase COX II Cytochrome c oxidase subunit II mtDNA Mitochondrial DNA NEFA Nonesterified fatty acid PCR Polymerase chain reaction PGC-1 Peroxisome proliferator-activated receptor- coactivator-1 RPE Rating of perceived exertion VAS visual analogue scale Additional file Footnotes Competing interests This study was supported in part by a research fund from the KOHJIN Life Sciences Company, Ltd

Impaired Glutathione Recycling in Dementia As shown by Irene Martinez de Toda et al 2019 (8) data, patients with dementia have a reduction in both the enzymes (GR and GP) that recycle glutathione

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