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Indeed, given that colorectal cancer cell lines display increased expression of H 2 S-synthesising enzymes, increased expression of SOP enzymes affords a higher capacity of these cells to dispose of excess H 2 S while stimulating cell bioenergetics

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Integrated analyses of these modalities have consequently led to the emergence of prognostic molecular subgroups associated with distinctive copy number changes, transcriptional signatures, and DNA methylation profiles, with varying levels of immunologic infiltration 2,4,11,13

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doi: 10.1017/S0007114508944135

Possible contributions of the gut microbiota remain largely unexplored to date, but merit investigation