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A placebo-controlled study]
Additionally, downstream of SDF1 (CXCL12) binding to the G protein-coupled receptor CXC chemokine receptor 4 (CXCR4), the PH domains of PLC1 promote lipase independent activation of Rap1, which leads to 2-integrin-mediated recruitment and adhesion of T-cells to sites of inflammation [38]
(33896531) However, the added benefit of this additional dose is unclear
