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Administration of an agent that stimulates alpha-1 receptors causes smooth muscle contraction in peripheral blood vessels, leading to a profound increase in systemic vascular resistance and mean arterial pressure
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A., & Schoenfeld, B
12.2.2 Potential antagonistic effects Conversely, curcumin has been shown to interfere with the action of other chemotherapeutic drugs (e.g., cyclophosphamide, doxorubicin) by activating certain detoxification pathways (like ABC transporters) that pump the drugs out of cancer cells, thereby reducing their effectiveness (244)
Zrzavy T, Hametner S, Wimmer I, Butovsky O, Weiner HL, Lassmann H
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