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Extrinsic apoptosis is initiated through the activation of caspase-8, while intrinsic apoptosis is mediated by the mitochondrial release of cytochrome c and SMAC/DIABLO, leading to the activation of caspase-9, which in turn activates downstream effector caspases such as caspase-3 and caspase-7 [112, 114]

23 , S580S584 (2008)

Andrade-Cetto A, Vazquez RC

Researchers begin focusing on the critical role of non-coding RNA in diverse cellular processes

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