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At a molecular level, L-theanine is structurally remarkably similar to L-glutamate and L-glutamine, which are the primary excitatory neurotransmitters in the human brain

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For instance, in the brain tissue of patients with Alzheimer's disease, the peroxidation product 4-HNE can bind covalently to critical neuronal mitochondrial, membrane and cytosolic proteins via Michael addition reactions

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2020;48(D1):D445D453
