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Fertility was normal in the offspring of mice exposed daily from before birth ( in utero ) through sexual maturity at daily exposures (AUC) of approximately 60 times higher than human exposures at the recommended 200 mg daily dose

and 24 healthy volunteers (12 females, 12 males, mean age 40.5 years, range 3065 years)

Van Schoor NM, Heymans MW, Lips P

10.1016/j.phrs.2019.104554 127

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unlike the other calibration curve spectral reads, the one with -HPC disappeared entirely from the spectrum