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These inflammatory mediators further damage neurons and disrupt the BBB, allowing peripheral immune cells to infiltrate the CNS ( The interaction between excitotoxicity and neuroinflammation is critical for the development of long-term neurodegeneration

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Microneedling creates thousands of microchannels, typically at 0.52.0 mm depth, that increase the permeability of the stratum corneum

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This iterative approach prevents both under-treatment and unnecessary over-treatment as conditions evolve

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It promotes hair growth by prolonging the anagen phase, shortening the telogen phase, and enlarging miniaturized hair follicles (Figure 2B) [29,30]

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