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Because B12 is so closely linked to energy production and normal bodily function, it has become a common supplement in wellness and weight-loss settings

It also supports the creation of red blood cells, which prevents anaemia and ensures our body gets enough oxygen

doi: 10.1248/bpb.29.1042

Now if all of the methyl groups on methionine only went to make the bodys' creatine usage (1.3 gm per day), this might be sufficient, BUT, you use 2-3 times this amount of creatine, and production of creatine is only about 40% of all methylation, so you have to cycle methionine at least 5-10 times, so there has to be an extensive cycling of both folate and B12.This is assuming optimal function of SHMT (vitamin B6 dependent), MTHFR (vitamin B2/B3 dependent) and MTRR (vitamin B2/B3 dependent)

Moreover, it also showed promising results in preventing intestinal absorption and permeability impairments during chemotherapy [97,98,107,109,110,111]

The mechanism linking these effects is well-documented in the growth hormone literature