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Insights into direct nose to brain delivery: current status and future perspective

With branded products commanding having experienced intermittent supply constraints, compounding pharmacies stepped in to fill the gapoperating under Section 503A of the Federal Food, Drug, and Cosmetic Act, which exempts qualifying compounders from certain FDA requirements, including CGMP compliance, labeling requirements, and premarket approval

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In the absence of heparin, c-MET and HGF were eluted as two separate peaks in SEC (Fig