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Int J Biochem Cell Biol 2010;42:1094104

Best practices for optimal vitamin B12 absorption To ensure you're getting the most from your B12 intake : Consider your individual health status : Factors like age, gastrointestinal health, and medication use should be considered when deciding whether to take B12 on an empty stomach or with food

Im not telling people to go get it, but I say, do your research and talk to your doctor or whoever else is going to do this, and personally decide if this is for you, but I am not personally recommending it