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The methylene-THF that is generated is oxidized to 10-formyl-THF via the methylene tetrahydrofolate dehydrogenase 2 (MTHFD2) catalyzed reaction which simultaneously reduces NAD + to NADH

In general, GPX exerts the role of oxidative stress by catalyzing the reduction of H 2 O 2 and organic hydroperoxides to water and corresponding alcohols, respectively

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