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Selectivity of NNMT inhibitors Test compounds were screened in biochemical assays for activity against three structurally similar methyltransferases, including catechol-O-methyltransferase (COMT), DNA (cytosine-5)-methyltransferase 1 (DNMT1), and protein arginine methyltransferase 3 (PRMT3)

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But the recommended daily amount of vitamin B-12 for adults is only 2.4 micrograms (mcg)

Nutrients like choline, methionine, inositol and vitamin B12 may contribute to key processes, such as methylation and one-carbon metabolism, that may influence how the body regulates metabolic activity, cellular energy production and fat transport