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An extensively utilized strategy for chemical ligation and peptide stapling involves the Cu(I)-catalyzed azidealkyne 1,3-dipolar Huisgen cycloaddition, commonly known as the CuAAC click reaction or the strain-promoted azidealkyne cycloaddition (SPAAC) (see Section )

In particular, amino acids are capable of functioning as signaling molecules

Additionally, the Epitalon peptide is credited with enhancing immune function

ClinicalTrials.gov [online], US National Library of Science

*Correspondence: Aristeidis A

Abnormal TGF-beta-1 signaling degrades the extracellular matrix and stimulates nerve growth factor, potentially increasing pain