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It may also regulate melanin production by the release of the -melanocyte stimulating hormone and the precipitation of zinc-2-glycoprotein in tissues

Think of it like this: if you cover a garden sprinkler for a few hours, when you uncover it, all that built-up pressure makes it spray harder for the next 1824 hours

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Among these, conjugated and secondary BAs, particularly taurocholic acid (TCA) and deoxycholic acid (DCA), exert notable effects on MDSCs

Cureus 14:e22711

Activation of TGR5 classically triggers Gs-cAMP-PKA signaling, which often exerts anti-inflammatory effects