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The role of glutathione metabolism in chronic illness development and its potential use as a novel therapeutic target

Introduction Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder characterized by impaired communication and social interaction, as well as repetitive/stereotyped behaviors ( Admittedly, numerous publications have indicated that the pathogenesis of ASD was affected by immune dysregulation/inflammation, oxidative stress, and mitochondrial dysfunction ( Strikingly, existing evidence has indicated that Nrf2 plays an important role in immune dysregulation/inflammation, oxidative stress, and mitochondrial dysfunction