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From apixaban, an anticoagulant used to treat and prevent blood clots and stroke, to bixafen, a pyrazole-carboxamide fungicide used to control diseases of rapeseed and cereal plants, the remarkable prevalence of pyrazole scaffolds in a diverse array of bioactive molecules has prompted medicinal and organic chemists to investigate novel approaches in creating pyrazole-containing compounds for various applications [174]

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S., Chamara, K

In summary, aberrant activation or dysregulation of L-serine-related metabolic enzymes and metabolic pathways is an important mechanism that promotes the malignant progression of tumors, and the heterogeneity of PHDGH in tumors may be a marker of tumor metastasis

Efficacy of sodium tanshinone IIA sulfonate in patients with non-ST elevation acute coronary syndrome undergoing percutaneous coronary intervention: results from a multicentre, controlled, randomized trial

Cereblon-based PROTACs: factors influencing efficacy The efficacy of cereblon-based PROTACs depends directly on the absence of mutations that interfere with the binding of the degrader to the protein, or indirectly, on mutations that interfere with the formation of the E3 ubiquitin ligase CRL4 CRBN complex, such as mutations that interfere with the binding between cereblon and the DDB1 protein