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[DOI] [PubMed] [Google Scholar] 47.Kalivas PW, Lalumiere RT, Knackstedt L, et al

Levels from infancy to adolescence increase and plateau in association with Tanner stages of puberty and then slowly decline with age starting in the late twenties [9,10]

Additionally, in vitro studies have demonstrated that zinc chelation inhibits AID activity, suggesting that age-associated changes in zinc homeostasis might further exacerbate the reduction in AID functionality [368]

Glutathione levels also are lower and oxidative stress is higher in conditions associated with mitochondrial dysfunction, including ageing, HIV infection, diabetes, neurodegenerative disorders, cardiovascular disorders, neurometabolic diseases, cancer, obesity and other conditions

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