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Increased TMAO levels are caused by lower clearance and increased synthesis as a result of gut dysbiosis, a weakened intestinal barrier, and increased hepatic enzyme activity

However, research is still limited and further studies are needed.2 3

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Calculation: The content of L-carnitine in the sample is calculated using a data processing system or according to the following formula (the blank value must be subtracted from the calculation result): Where: X the concentration of the analyte in the sample, in milligrams per kilogram (mg/kg)

It has been suggested that VHT and VHE may be promoted by carnitine deficiency, either pre-existing or deficiency induced by VPA [134]

Zeiler FA, Sader N, Gillman LM, West M