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Any abnormalities can be signs of BPH, prostate cancer, or prostatitis

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Both 400 mcg/day and 5 mg /day FA significantly increased plasma folate and decreased plasma Hcy 5mg/day - but not 400 mcg/day folic acid improves blood vessel cell function in coronary artery disease patients as measured by flow mediated dilatation [27]

[1] Causes of generalised hyperpigmentation include excessive sun exposure, drugs, Addisons disease and nutritional disorder such as Vitamin B12 deficiency

Zhao et al., 2018